Vaginal estrogen therapy is associated with increased Lactobacillus in the urine of postmenopausal women with overactive bladder symptoms.

ABSTRACT:

Background

Previous work has shown that the vaginal microbiome decreases in Lactobacillus predominance and becomes more diverse after menopause. It has also been shown that estrogen therapy restores Lactobacillus dominance in the vagina and that topical estrogen is associated with overactive bladder symptom improvement. We now know that the bladder contains a unique microbiome and that increased bladder microbiome diversity is associated with overactive bladder. However, there is no understanding of how quickly each pelvic floor microbiome responds to estrogen or if those changes are associated with symptom improvement.

Objective

This study aimed to determine if estrogen treatment of postmenopausal women with overactive bladder decreases urobiome diversity.

Study design</

SUBMITTER: Thomas-White K 

PROVIDER: S-EPMC7609597 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature