C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density.

ABSTRACT: Synapses are dynamic connections that underlie essential functions of the nervous system. The addition, removal, and maintenance of synapses govern the flow of information in neural circuits throughout the lifetime of an animal. While extensive studies have elucidated many intrinsic mechanisms that neurons employ to modulate their connections, increasing evidence supports the roles of non-neuronal cells, such as glia, in synapse maintenance and circuit function. We previously showed that C. elegans epidermis regulates synapses through ZIG-10, a cell-adhesion protein of the immunoglobulin domain superfamily. Here we identified a member of the Pals1/MPP5 family, MAGU-2, that functions in the epidermis to modulate phagocytosis and the number of synapses by regulating ZIG-10 localizatio

SUBMITTER: Cherra SJ 

PROVIDER: S-EPMC7609615 | biostudies-literature | 2020 Sep-Dec

REPOSITORIES: biostudies-literature