Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.

ABSTRACT:

Background

Uterine leiomyomas, the most common tumors of the female reproductive system, are characterized by excessive deposition of disordered stiff extracellular matrix and fundamental alteration in the mechanical signaling pathways. Specifically, these alterations affect the normal dynamic state of responsiveness to mechanical cues in the extracellular environment. These mechanical cues are converted through integrins, cell membrane receptors, to biochemical signals including cytoskeletal signaling pathways to maintain mechanical homeostasis. Leiomyoma cells overexpress β1 integrin and other downstream mechanical signaling proteins. We previously reported that simvastatin, an antihyperlipidemic drug, has antileiomyoma effects through cellular, animal model, and epidemiologic st

SUBMITTER: Afrin S 

PROVIDER: S-EPMC7609626 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature