Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice.

ABSTRACT: Progranulin is a secreted neurotrophin that assists in the autophagolysosomal pathways that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. We showed that patients with multiple sclerosis (MS) have high levels of circulating progranulin and that its depletion in a mouse model by a monoclonal antibody aggravates MS-like experimental autoimmune encephalomyelitis (EAE). However, unexpectedly, progranulin-deficient mice (Grn^-/-) were resistant to EAE, and this resistance was fully restored by wild-type bone marrow transplantation. FACS analyses revealed a loss of MHC-II-positive antigen-presenting cells in Grn^-/- mice and a reduction in the number of CD8+ and CD4+ T-cells along with a strong increase in the number of scavenger receptor c

SUBMITTER: Schmitz K 

PROVIDER: S-EPMC7609649 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature