Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread.

ABSTRACT: Evidence-based public health approaches that minimize the introduction and spread of new SARS-CoV-2 transmission clusters are urgently needed in the United States and other countries struggling with expanding epidemics. Here we analyze 247 full-genome SARS-CoV-2 sequences from two nearby communities in Wisconsin, USA, and find surprisingly distinct patterns of viral spread. Dane County had the 12^th known introduction of SARS-CoV-2 in the United States, but this did not lead to descendant community spread. Instead, the Dane County outbreak was seeded by multiple later introductions, followed by limited community spread. In contrast, relatively few introductions in Milwaukee County led to extensive community spread. We present evidence for reduced viral spread in both counties fol

SUBMITTER: Moreno GK 

PROVIDER: S-EPMC7609670 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature