Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor.

ABSTRACT: Glucocorticoid (GC) actions are mediated through two closely related ligand-dependent transcription factors, the GC receptor (GR) and the mineralocorticoid receptor (MR). Given the wide and effective use of GCs to combat skin inflammatory diseases, it is important to understand the relative contribution of these receptors to the transcriptional response to topical GCs. We evaluated the gene expression profiles in the skin of mice with epidermal-specific loss of GR (GR^EKO), MR (MR^EKO), or both (double KO; DKO) in response to dexamethasone (Dex). The overall transcriptional response was abolished in GR^EKO and DKO skin suggesting dependence of the underlying dermis on the presence of epidermal GR. Indeed, the observed dermal GC resistance correlated with a con

SUBMITTER: Sevilla LM 

PROVIDER: S-EPMC7609727 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature