Disruption of Physiological Rhythms Persist Following Cessation of Cigarette Smoke Exposure in Mice.

ABSTRACT:

Background

Physiological rhythms in mammals are essential for maintaining health, whereas disruptions may cause or exacerbate disease pathogenesis. As such, our objective was to characterize how cigarette smoke exposure affects physiological rhythms of otherwise healthy mice using telemetry and cosinor analysis.

Methods

Female BALB/c mice were implanted with telemetry devices to measure body temperature, heart rate, systolic blood pressure (SBP), and activity. Following baseline measurements, mice were exposed to cigarette smoke for approximately 50 min twice daily during weekdays over 24 weeks. Physiological parameters were recorded after 1, 4, 8, and 24 weeks of exposure or after 4 weeks cessation following 4 weeks of cigarette smoke exposure.

Results

Acute cigarett

SUBMITTER: Vanderstocken G 

PROVIDER: S-EPMC7609783 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature