Alterations of the Gut Microbiome Composition and Lipid Metabolic Profile in Radiation Enteritis.

ABSTRACT: Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy. Although studies have shown the changes of this disease at clinical, pathological and other levels, the dynamic characteristics of local microbiome and metabolomics are hitherto unknown. We aimed to examine the multi-omics features of the gut microecosystem, determining the functional correlation between microbiome and lipid metabolites during RE activity. By delivering single high-dose irradiation, a RE mouse model was established. High-throughput 16S rDNA sequencing and global lipidomics analysis were performed to examine microbial and lipidomic profile changes in the gut microecosystem. Spearman correlation analysis was used to determine the functional correlation between bacteria and metabolite

SUBMITTER: Li Y 

PROVIDER: S-EPMC7609817 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature