In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats†.

ABSTRACT: Sex steroids regulate insulin sensitivity and glucose metabolism. We had characterized a lean type 2 diabetes (T2D) rat model using gestational low-protein (LP) diet programming. Our objective was to identify if endocrine dysfunction leading to decreased sex hormone levels will precede the development of T2D and if steroid replacement will prevent the onset of the disease. Pregnant rats were fed control or isocaloric LP diet from gestational day 4 until delivery. Normal diet was given to all mothers after delivery and to pups after weaning. LP offspring developed glucose intolerance and insulin resistance at 4 months. We measured sex steroid hormone profiles and expression of key genes involved in steroidogenesis in testis and ovary. Furthermore, one-month old rats were implanted with 90-d

SUBMITTER: Blesson CS 

PROVIDER: S-EPMC7609843 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature