Lugol's Iodine-Enhanced Micro-CT: A Potential 3-D Imaging Method for Detecting Tongue Squamous Cell Carcinoma Specimens in Surgery.

ABSTRACT:

Background

A positive surgical margin (PSM) following oral cancer resection results in local recurrence and poor prognosis. Mono-block tumor specimens, especially from the tumor base, are difficult to evaluate. This inaccurate sampling ultimately leads to a false pathological diagnosis. Lugol's iodine (I₂-IK)-enhanced micro-CT is an emerging method to image tumor specimens. This study explores the feasibility of I₂-IK-enhanced micro-CT to evaluate the surgical margin for tongue squamous cell carcinoma (TSCC) specimens and to further seek optimal staining parameters.

Methods

Rabbit tongue tissues and human TSCC samples were imaged via I₂-IK-enhanced micro-CT. The optimal I₂-IK concentration and staining time were determined b

SUBMITTER: Xia CW 

PROVIDER: S-EPMC7609877 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature