ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer.

ABSTRACT:

Objective

Triple-negative (PR^-, ER^-, HER-2^-) breast cancer (TNBC) is regarded as more aggressive and more likely to recur after medical care. Emerging evidence has demonstrated that the circadian clock system regulates cell-signaling pathways critical to cancer cell proliferation, survival and metastasis, meaning that it could be a good candidate for TNBC treatment. As such, the aim of the current study was to examine the molecular mechanism by which the circadian clock system contributes to cancer progression in TNBC.

Methods

Cancer cells and primary breast cancer tissues were immunostained for the measurement of circadian clock proteins (CLOCK, BMAL1 and PER1) and acetylserotonin methyltransferase (ASMT). The association between ASMT and cl

SUBMITTER: Xie F 

PROVIDER: S-EPMC7609885 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature