In vitro Synergistic Activity of Antimicrobial Combinations Against bla _KPC and bla _NDM-Producing Enterobacterales With bla _IMP or mcr Genes.

ABSTRACT: Carbapenemase-producing Enterobacterales have become a severe public health concern because of their rapidly transmissible resistance elements and limited treatment options. The most effective antimicrobial combinations against carbapenemase-producing Enterobacterales are currently unclear. Here, we aimed to assess the therapeutic effects of seven antimicrobial combinations (colistin-meropenem, colistin-tigecycline, colistin-rifampicin, colistin-erythromycin, meropenem-tigecycline, meropenem-rifampicin, and meropenem-tigecycline-colistin) against twenty-four carbapenem-producing Enterobacterales (producing bla _KPC, bla _NDM, coexisting bla _NDM and bla _IMP, and coexisting mcr-1/8/9 and bla<

SUBMITTER: Zhou C 

PROVIDER: S-EPMC7609915 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature