Recent Advances in Severe Asthma: From Phenotypes to Personalized Medicine.

ABSTRACT: This review focuses on recent clinical and translational discoveries in severe and uncontrolled asthma that now enable phenotyping and personalized therapies in these patients. Although asthma is common in both children and adults and typically responds to standard therapies, a subset of individuals with asthma experience severe and/or persistent symptoms despite appropriate therapies. Airflow obstruction leading to frequent symptoms requiring higher levels of controller therapy is the cardinal feature of severe asthma, but the underlying molecular mechanisms, or endotypes, are diverse and variable between individuals. Two major risk factors that contribute to severe asthma are genetics and environmental exposures that modulate immune responses, and although these often interact in complex

SUBMITTER: Schoettler N 

PROVIDER: S-EPMC7609962 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature