Prevalence, Characteristics, and Outcomes of Incidental IgA Glomerular Deposits in Donor Kidneys.

ABSTRACT:

Introduction

Incidental IgA deposits in donor kidneys have unknown sequelae and may predate clinical kidney disease if primed by adverse immunologic or hemodynamic stimuli or may remain dormant.

Methods

The presence of incidental IgA in post-implantation (T₀) biopsies from living (LDK) and deceased donor (DDK) kidneys, and its relationship to post-transplant patient and graft outcomes was investigated in an ethnically diverse US population at a large transplant center.

Results

Mesangial IgA was present in 20.4% of 802 T₀ biopsies; 13.2% and 24.5% of LDK and DDK, respectively. Donors with incidental IgA deposits were more likely to have hypertension and be of Hispanic or Asian origin. Intensity of IgA staining was 1+ (57.3%), 2+ (26.8%), or 3+ (15

SUBMITTER: Gaber LW 

PROVIDER: S-EPMC7609995 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature