Dataset Information

Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population-based study.

ABSTRACT:

Aims/introduction

We investigated the risk of incident type 2 diabetes according to the cumulative exposure to obesity or metabolic syndrome (MetS) during annual or biennial health examinations.

Materials and methods

The Korean National Health Insurance Service datasets from 2002 to 2017 were used for this retrospective longitudinal study. The risk for type 2 diabetes was analyzed according to the cumulative exposure to obesity and MetS among individuals who underwent four health examinations from 2009 to 2012 or 2013 (n = 2,851,745).

Results

During examinations, 28.56 and 17.86% of the total participants showed fluctuations in metabolic health state and obesity, respectively. During a mean 5.01 years of follow up, 98,950 new type 2 diabetes cases developed. The risk for type 2 diabetes increased with the increase in exposure to MetS (hazard ratio [HR] 2.92, 95% confidence interval [CI] 2.86-2.99; HR 4.96, 95% CI 4.85-5.08; HR 7.46, 95% CI 7.30-7.63; HR 12.24, 95% CI 12.00-12.49 in groups with number of exposures one to four, respectively) and obesity (HR 1.60, 95% CI 1.56-1.65; HR 1.87, 95% CI 1.81-1.92; HR 2.25, 95% CI 2.19-2.31; HR 3.46, 95% CI 3.41-3.51 in groups with number of exposures one to four, respectively), showing a more detrimental effect of cumulative exposure to MetS, when compared with the exposure to obesity.

Conclusions

Metabolic health and obesity fluctuated within a relatively short period of 4-5 years. Although the impact was much greater for MetS than for obesity, the cumulative duration of both obesity and MetS was associated with an increased risk of type 2 diabetes in a dose-response manner. Therefore, continuously maintaining metabolic health and normal weight is crucial to prevent incident type 2 diabetes.

SUBMITTER: Lee YB

PROVIDER: S-EPMC7610118 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population-based study.

Lee You-Bin YB Kim Da Hye DH Kim Seon Mee SM Kim Nan Hee NH Choi Kyung Mook KM Baik Sei Hyun SH Park Yong Gyu YG Han Kyungdo K Yoo Hye Jin HJ

Journal of diabetes investigation 20200628 6

<h4>Aims/introduction</h4>We investigated the risk of incident type 2 diabetes according to the cumulative exposure to obesity or metabolic syndrome (MetS) during annual or biennial health examinations.<h4>Materials and methods</h4>The Korean National Health Insurance Service datasets from 2002 to 2017 were used for this retrospective longitudinal study. The risk for type 2 diabetes was analyzed according to the cumulative exposure to obesity and MetS among individuals who underwent four health ...[more]

PMID: 32449283

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Dataset Information

Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population-based study.

Aims/introduction

Materials and methods

Results

Conclusions

Publications

Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population-based study.

Similar Datasets

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