Multiscale Characterization of Embryonic Long Bone Mineralization in Mice.

ABSTRACT: Long bone mineralization occurs through endochondral ossification, where a cartilage template mineralizes into bone-like tissue with a hierarchical organization from the whole bone-scale down to sub-nano scale. Whereas this process has been extensively studied at the larger length scales, it remains unexplored at some of the smaller length scales. In this study, the changes in morphology, composition, and structure during embryonic mineralization of murine humeri are investigated using a range of high-resolution synchrotron-based imaging techniques at several length scales. With micro- and nanometer spatial resolution, the deposition of elements and the shaping of mineral platelets are followed. Rapid mineralization of the humeri occurs over approximately four days, where mineral to matrix

SUBMITTER: Silva Barreto I 

PROVIDER: S-EPMC7610310 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature