Structural cells are key regulators of organ-specific immune responses.

ABSTRACT: The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens¹. Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity². However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence^3-5. To advance our understanding of immunology outside the haematopoietic system, here we systematically investigate the regulation of immune genes in the three major types of structural cells: epithelium, endothelium and fibroblasts. We characterize these cell types across twelve organs in mice, using cellular phenotyping, transcriptome sequencing, chromatin a

SUBMITTER: Krausgruber T 

PROVIDER: S-EPMC7610345 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature