Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories.

ABSTRACT: The transition from adolescence to adulthood is a period when ongoing brain development coincides with a substantially increased risk of psychiatric disorders. The developmental brain changes accounting for this emergent psychiatric symptomatology remain obscure. Capitalizing on a unique longitudinal dataset that includes in vivo myelin-sensitive magnetization transfer (MT) MRI scans, we show that this developmental period is characterized by brain-wide growth in MT trajectories within both gray matter and adjacent juxtacortical white matter. In this healthy population, the expression of common developmental traits, namely compulsivity and impulsivity, is tied to a reduced growth of these MT trajectories in frontostriatal regions. This reduction is most marked in dorsomedial and dorsolater

SUBMITTER: Ziegler G 

PROVIDER: S-EPMC7610393 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature