The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis.

ABSTRACT: The response to antipsychotic treatment in schizophrenia appears to vary, and as such it has been proposed that different subtypes of schizophrenia exist, defined by treatment-response. This has not been formally examined using meta-analysis. Randomised controlled trials comparing placebo and antipsychotics in acute treatment of schizophrenia listed in PubMed, EMBASE and PsycINFO from inception until 30 November 2018 were examined. Relative variability of symptomatic improvement in antipsychotic-treated individuals compared to placebo-treated individuals was quantified using coefficient of variation ratio (CVR). Mean difference in symptom change was quantified using Hedges' g. In addition, individual patient data from two clinical trials was examined in terms of both the distribution of to

SUBMITTER: McCutcheon RA 

PROVIDER: S-EPMC7610422 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature