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ABSTRACT:
SUBMITTER: Surendran P
PROVIDER: S-EPMC7610439 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Surendran Praveen P Feofanova Elena V EV Lahrouchi Najim N Ntalla Ioanna I Karthikeyan Savita S Cook James J Chen Lingyan L Mifsud Borbala B Yao Chen C Kraja Aldi T AT Cartwright James H JH Hellwege Jacklyn N JN Giri Ayush A Tragante Vinicius V Thorleifsson Gudmar G Liu Dajiang J DJ Prins Bram P BP Stewart Isobel D ID Cabrera Claudia P CP Eales James M JM Akbarov Artur A Auer Paul L PL Bielak Lawrence F LF Bis Joshua C JC Braithwaite Vickie S VS Brody Jennifer A JA Daw E Warwick EW Warren Helen R HR Drenos Fotios F Nielsen Sune Fallgaard SF Faul Jessica D JD Fauman Eric B EB Fava Cristiano C Ferreira Teresa T Foley Christopher N CN Franceschini Nora N Gao He H Giannakopoulou Olga O Giulianini Franco F Gudbjartsson Daniel F DF Guo Xiuqing X Harris Sarah E SE Havulinna Aki S AS Helgadottir Anna A Huffman Jennifer E JE Hwang Shih-Jen SJ Kanoni Stavroula S Kontto Jukka J Larson Martin G MG Li-Gao Ruifang R Lindström Jaana J Lotta Luca A LA Lu Yingchang Y Luan Jian'an J Mahajan Anubha A Malerba Giovanni G Masca Nicholas G D NGD Mei Hao H Menni Cristina C Mook-Kanamori Dennis O DO Mosen-Ansorena David D Müller-Nurasyid Martina M Paré Guillaume G Paul Dirk S DS Perola Markus M Poveda Alaitz A Rauramaa Rainer R Richard Melissa M Richardson Tom G TG Sepúlveda Nuno N Sim Xueling X Smith Albert V AV Smith Jennifer A JA Staley James R JR Stanáková Alena A Sulem Patrick P Thériault Sébastien S Thorsteinsdottir Unnur U Trompet Stella S Varga Tibor V TV Velez Edwards Digna R DR Veronesi Giovanni G Weiss Stefan S Willems Sara M SM Yao Jie J Young Robin R Yu Bing B Zhang Weihua W Zhao Jing-Hua JH Zhao Wei W Zhao Wei W Evangelou Evangelos E Aeschbacher Stefanie S Asllanaj Eralda E Blankenberg Stefan S Bonnycastle Lori L LL Bork-Jensen Jette J Brandslund Ivan I Braund Peter S PS Burgess Stephen S Cho Kelly K Christensen Cramer C Connell John J Mutsert Renée de R Dominiczak Anna F AF Dörr Marcus M Eiriksdottir Gudny G Farmaki Aliki-Eleni AE Gaziano J Michael JM Grarup Niels N Grove Megan L ML Hallmans Göran G Hansen Torben T Have Christian T CT Heiss Gerardo G Jørgensen Marit E ME Jousilahti Pekka P Kajantie Eero E Kamat Mihir M Käräjämäki AnneMari A Karpe Fredrik F Koistinen Heikki A HA Kovesdy Csaba P CP Kuulasmaa Kari K Laatikainen Tiina T Lannfelt Lars L Lee I-Te IT Lee Wen-Jane WJ Linneberg Allan A Martin Lisa W LW Moitry Marie M Nadkarni Girish G Neville Matt J MJ Palmer Colin N A CNA Papanicolaou George J GJ Pedersen Oluf O Peters James J Poulter Neil N Rasheed Asif A Rasmussen Katrine L KL Rayner N William NW Mägi Reedik R Renström Frida F Rettig Rainer R Rossouw Jacques J Schreiner Pamela J PJ Sever Peter S PS Sigurdsson Emil L EL Skaaby Tea T Sun Yan V YV Sundstrom Johan J Thorgeirsson Gudmundur G Esko Tõnu T Trabetti Elisabetta E Tsao Philip S PS Tuomi Tiinamaija T Turner Stephen T ST Tzoulaki Ioanna I Vaartjes Ilonca I Vergnaud Anne-Claire AC Willer Cristen J CJ Wilson Peter W F PWF Witte Daniel R DR Yonova-Doing Ekaterina E Zhang He H Aliya Naheed N Almgren Peter P Amouyel Philippe P Asselbergs Folkert W FW Barnes Michael R MR Blakemore Alexandra I AI Boehnke Michael M Bots Michiel L ML Bottinger Erwin P EP Buring Julie E JE Chambers John C JC Chen Yii-Der Ida YI Chowdhury Rajiv R Conen David D Correa Adolfo A Davey Smith George G Boer Rudolf A de RA Deary Ian J IJ Dedoussis George G Deloukas Panos P Di Angelantonio Emanuele E Elliott Paul P Felix Stephan B SB Ferrières Jean J Ford Ian I Fornage Myriam M Franks Paul W PW Franks Stephen S Frossard Philippe P Gambaro Giovanni G Gaunt Tom R TR Groop Leif L Gudnason Vilmundur V Harris Tamara B TB Hayward Caroline C Hennig Branwen J BJ Herzig Karl-Heinz KH Ingelsson Erik E Tuomilehto Jaakko J Järvelin Marjo-Riitta MR Jukema J Wouter JW Kardia Sharon L R SLR Kee Frank F Kooner Jaspal S JS Kooperberg Charles C Launer Lenore J LJ Lind Lars L Loos Ruth J F RJF Majumder Abdulla Al Shafi AAS Laakso Markku M McCarthy Mark I MI Melander Olle O Mohlke Karen L KL Murray Alison D AD Nordestgaard Børge Grønne BG Orho-Melander Marju M Packard Chris J CJ Padmanabhan Sandosh S Palmas Walter W Polasek Ozren O Porteous David J DJ Prentice Andrew M AM Province Michael A MA Relton Caroline L CL Rice Kenneth K Ridker Paul M PM Rolandsson Olov O Rosendaal Frits R FR Rotter Jerome I JI Rudan Igor I Salomaa Veikko V Samani Nilesh J NJ Sattar Naveed N Sheu Wayne H-H WH Smith Blair H BH Soranzo Nicole N Spector Timothy D TD Starr John M JM Sebert Sylvain S Taylor Kent D KD Lakka Timo A TA Timpson Nicholas J NJ Tobin Martin D MD van der Harst Pim P van der Meer Peter P Ramachandran Vasan S VS Verweij Niek N Virtamo Jarmo J Völker Uwe U Weir David R DR Zeggini Eleftheria E Charchar Fadi J FJ Wareham Nicholas J NJ Langenberg Claudia C Tomaszewski Maciej M Butterworth Adam S AS Caulfield Mark J MJ Danesh John J Edwards Todd L TL Holm Hilma H Hung Adriana M AM Lindgren Cecilia M CM Liu Chunyu C Manning Alisa K AK Morris Andrew P AP Morrison Alanna C AC O'Donnell Christopher J CJ Psaty Bruce M BM Saleheen Danish D Stefansson Kari K Boerwinkle Eric E Chasman Daniel I DI Levy Daniel D Newton-Cheh Christopher C Munroe Patricia B PB Howson Joanna M M JMM
Nature genetics 20201123 12
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10<sup>-8</sup>), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% ...[more]