Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.

ABSTRACT: Recent population-based^1-4 and clinical studies⁵ have identified a range of factors associated with human gut microbiome variation. Murine quantitative trait loci⁶, human twin studies⁷ and microbiome genome-wide association studies^1,3,8-12 have provided evidence for genetic contributions to microbiome composition. Despite this, there is still poor overlap in genetic association across human studies. Using appropriate taxon-specific models, along with support from independent cohorts, we show an association between human host genotype and gut microbiome variation. We also suggest that interpretation of applied analyses using genetic associations is complicated by the probable overlap between genetic contributions and heritable component

SUBMITTER: Hughes DA 

PROVIDER: S-EPMC7610462 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature