Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
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ABSTRACT:
SUBMITTER: Zheng J
PROVIDER: S-EPMC7610464 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Zheng Jie J Haberland Valeriia V Baird Denis D Walker Venexia V Haycock Philip C PC Hurle Mark R MR Gutteridge Alex A Erola Pau P Liu Yi Y Luo Shan S Robinson Jamie J Richardson Tom G TG Staley James R JR Elsworth Benjamin B Burgess Stephen S Sun Benjamin B BB Danesh John J Runz Heiko H Maranville Joseph C JC Martin Hannah M HM Yarmolinsky James J Laurin Charles C Holmes Michael V MV Liu Jimmy Z JZ Estrada Karol K Santos Rita R McCarthy Linda L Waterworth Dawn D Nelson Matthew R MR Smith George Davey GD Butterworth Adam S AS Hemani Gibran G Scott Robert A RA Gaunt Tom R TR
Nature genetics 20200907 10
The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here we estimated the effects of 1,002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization. Of 413 associations supported by evidence from MR, 130 (31.5%) were not supported by results of colocalization analyses, suggesting that genetic confound ...[more]
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