Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes.

ABSTRACT: Mono-axial functionalised octahedral diazido Pt(iv) complexes trans, trans, trans-[Pt(py)₂(N₃)₂(OR₁)(OR₂)] (OR₁ = OH and OR₂ = anticancer agent coumarin-3 carboxylate (cou, 2a), pyruvate dehydrogenase kinase (PDK) inhibitors 4-phenylbutyrate (PhB, 2b) or dichloroacetate (DCA, 2c)), and their di-axial functionalised analogues with OR₁ = DCA and OR₂ = cou (3a), PhB (3b), or DCA (3c) have been synthesised and characterised, including the X-ray crystal structures of complexes 2a, 3a, 3b and 3c. These complexes exhibit dark stability and have the potential to generate cytotoxic Pt(ii) species and free radicals selectively in cancer cells when

SUBMITTER: Shi H 

PROVIDER: S-EPMC7610473 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature