Diminished modulation of motor cortical reactivity during context-based action observation in schizophrenia.

ABSTRACT:

Background

Deficient mirror neuron system (MNS)-activity is associated with social cognition deficits in schizophrenia. However, it is not known how socio-emotional contexts modulate the MNS-response. In a Transcranial Magnetic Stimulation (TMS)-experiment, we aimed to compare putative MNS-responses to action observation stimuli with and without a context, in patients with schizophrenia and healthy subjects.

Method

TMS-evoked motor cortical reactivity was measured by single and paired [short interval intracortical inhibition (SICI) and facilitation (ICF)] pulse-paradigms in schizophrenia patients (n = 39) and healthy subjects (n = 28) while they observed three experimental-blocks: a static image, a neutral hand action (NA) and a context-based hand action (CA). The degree of

SUBMITTER: Bagewadi VI 

PROVIDER: S-EPMC7610505 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature