Closed mitosis requires local disassembly of the nuclear envelope.

ABSTRACT: At the end of mitosis, eukaryotic cells must segregate the two copies of their replicated genome into two new nuclear compartments¹. They do this either by first dismantling and later reassembling the nuclear envelope in an 'open mitosis' or by reshaping an intact nucleus and then dividing it into two in a 'closed mitosis'^2,3. Mitosis has been studied in a wide variety of eukaryotes for more than a century⁴, but how the double membrane of the nuclear envelope is split into two at the end of a closed mitosis without compromising the impermeability of the nuclear compartment remains unknown⁵. Here, using the fission yeast Schizosaccharomyces pombe (a classical model for closed mitosis⁵), genetics, live-cell imaging and electron tomograph

SUBMITTER: Dey G 

PROVIDER: S-EPMC7610560 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature