Closed-Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials.

ABSTRACT:

Background

High-frequency thalamic stimulation is an effective therapy for essential tremor, which mainly affects voluntary movements and/or sustained postures. However, continuous stimulation may deliver unnecessary current to the brain due to the intermittent nature of the tremor.

Objective

We proposed to close the loop of thalamic stimulation by detecting tremor-provoking movement states using local field potentials recorded from the same electrodes implanted for stimulation, so that the stimulation is only delivered when necessary.

Methods

Eight patients with essential tremor participated in this study. Patient-specific support vector machine classifiers were first trained using data recorded while the patient performed tremor-provoking movements. Then, the traine

SUBMITTER: He S 

PROVIDER: S-EPMC7610625 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature