Spinal astroglial cannabinoid receptors control pathological tremor.

ABSTRACT: Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated by cannabinoid receptors on astrocytes in the ventral horn of the spinal cord, where alternating limb movements are initiated. We first demonstrate that tremor is reduced in a mouse model of essential tremor after intrathecal injection of the cannabinoid analog WIN55,212-2. We investigate the underlying mechanism using electrophysiological recordings in spinal cord slices and show that endocannabinoids released from depolarized interneurons activate astrocytic cannabinoid receptors, causing an increase in intracellular Ca²⁺, subsequent release of purines and inhibition of excitatory neurotransmission. Finally, we show that the an

SUBMITTER: Carlsen EMM 

PROVIDER: S-EPMC7610740 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature