Association of dopamine D_2/3 receptor binding potential measured using PET and [¹¹C]-(+)-PHNO with post-mortem DRD_2/3 gene expression in the human brain.

ABSTRACT: Open access post-mortem transcriptome atlases such as the Allen Human Brain Atlas (AHBA) can inform us about mRNA expression of numerous proteins of interest across the whole brain, while in vivo protein binding in the human brain can be quantified by means of neuroreceptor positron emission tomography (PET). By combining both modalities, the association between regional gene expression and receptor distribution in the living brain can be approximated. Here, we compare the characteristics of D₂ and D₃ dopamine receptor distribution by applying the dopamine D_2/3 receptor agonist radioligand [¹¹C]-(+)-PHNO and human gene expression data. Since [¹¹C]-(+)-PHNO has a higher affinity for D₃ compared to D₂ receptors, we

SUBMITTER: Komorowski A 

PROVIDER: S-EPMC7610745 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature