Ion-channel regulation of response decorrelation in a heterogeneous multi-scale model of the dentate gyrus.

ABSTRACT: Heterogeneities in biological neural circuits manifest in afferent connectivity as well as in local-circuit components such as neuronal excitability, neural structure and local synaptic strengths. The expression of adult neurogenesis in the dentate gyrus (DG) amplifies local-circuit heterogeneities and guides heterogeneities in afferent connectivity. How do neurons and their networks endowed with these distinct forms of heterogeneities respond to perturbations to individual ion channels, which are known to change under several physiological and pathophysiological conditions? We sequentially traversed the ion channels-neurons-network scales and assessed the impact of eliminating individual ion channels on conductance-based neuronal and network models endowed with disparate local-circuit and

SUBMITTER: Mishra P 

PROVIDER: S-EPMC7610774 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature