Transparent support media for high resolution 3D printing of volumetric cell-containing ECM structures.

ABSTRACT: 3D bioprinting may revolutionize the field of tissue engineering by allowing fabrication of bio-structures with a high degree of complexity, fine architecture and heterogeneous composition. The printing substances in these processes are mostly based on biomaterials and living cells. As such, they generally possess weak mechanical properties and thus must be supported during fabrication in order to prevent the collapse of large, volumetric multi-layered printouts. In this work, we characterize a uniquely formulated media used to support printing of extracellular matrix-based biomaterials. We show that a hybrid material, comprised of calcium-alginate nanoparticles and xanthan gum, presents superb qualities that enable printing at high resolution of down to 10 microns, allowing fabrication of

SUBMITTER: Shapira A 

PROVIDER: S-EPMC7610779 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature