Neuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval.

ABSTRACT: Animal studies using selective serotonin reuptake inhibitors (SSRIs) and learning paradigms have demonstrated that serotonin is important for flexibility in executive functions and learning. SSRIs might facilitate relearning through neuroplastic processes and thus exert their clinical effects in psychiatric diseases where cognitive functioning is affected. However, translation of these mechanisms to humans is missing. In this randomized placebo-controlled trial, we assessed functional brain activation during learning and memory retrieval in healthy volunteers performing associative learning tasks aiming to translate facilitated relearning by SSRIs. To this extent, seventy-six participants underwent three MRI scanning sessions: (1) at baseline, (2) after three weeks of daily associative lea

SUBMITTER: Reed MB 

PROVIDER: S-EPMC7610799 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature