Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia.

ABSTRACT:

Background

The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor-blocking activity but causes cholinergic adverse events. Trospium is a peripherally restricted muscarinic receptor antagonist that reduces peripheral cholinergic effects of xanomeline. The efficacy and safety of combined xanomeline and trospium in patients with schizophrenia are unknown.

Methods

In this double-blind, phase 2 trial, we randomly assigned patients with schizophrenia in a 1:1 ratio to receive twice-daily xanomeline-trospium (increased to a maximum of 125 mg of xanomeline and 30 mg of trospium per dose) or placebo for 5 weeks. The primary end point was the change from baseline to week 5 in the total score on the Positive and Negative Syndrome Scal

SUBMITTER: Brannan SK 

PROVIDER: S-EPMC7610870 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature