Central anorexigenic actions of bile acids are mediated by TGR5.

ABSTRACT: Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain¹, yet their physiological role in the central nervous system is still largely unknown. Here we show that postprandial BAs can reach the brain and activate a negative-feedback loop controlling satiety in response to physiological feeding via TGR5, a G-protein-coupled receptor activated by multiple conjugated and unconjugated BAs² and an established regulator of peripheral metabolism^3-8. Notably, peripheral or central administration of a BA mix or a TGR5-specific BA mimetic (INT-777) exerted an anorexigenic effect in wild-type mice, while whole-body, neuron-specific or

SUBMITTER: Perino A 

PROVIDER: S-EPMC7610881 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature