Commensal Bacteroidetes protect against Klebsiella pneumoniae colonization and transmission through IL-36 signalling.

ABSTRACT: The microbiota primes immune defences but the identity of specific commensal microorganisms that protect against infection is unclear. Conversely, how pathogens compete with the microbiota to establish their host niche is also poorly understood. In the present study, we investigate the antagonism between the microbiota and Klebsiella pneumoniae during colonization and transmission. We discover that maturation of the microbiota drives the development of distinct immune defence programmes in the upper airways and intestine to limit K. pneumoniae colonization within these niches. Immune protection in the intestine depends on the development of Bacteroidetes, interleukin (IL)-36 signalling and macrophages. This effect of Bacteroidetes requires the polysaccharide utilization locus of their cons

SUBMITTER: Sequeira RP 

PROVIDER: S-EPMC7610889 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature