Flexible modulation of sequence generation in the entorhinal-hippocampal system.

ABSTRACT: Exploration, consolidation and planning depend on the generation of sequential state representations. However, these algorithms require disparate forms of sampling dynamics for optimal performance. We theorize how the brain should adapt internally generated sequences for particular cognitive functions and propose a neural mechanism by which this may be accomplished within the entorhinal-hippocampal circuit. Specifically, we demonstrate that the systematic modulation along the medial entorhinal cortex dorsoventral axis of grid population input into the hippocampus facilitates a flexible generative process that can interpolate between qualitatively distinct regimes of sequential hippocampal reactivations. By relating the emergent hippocampal activity patterns drawn from our model to empirica

SUBMITTER: McNamee DC 

PROVIDER: S-EPMC7610914 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature