TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.

ABSTRACT: Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses^1-3. Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosus^4,5-interacts with the endolysosomal transporter SLC15A4, an essential but poorly understood component of the endolysosomal TLR machinery also linked to autoimmune disease^4,6-9. Loss of this type-I-interferon-inducible protein, which we refer to as 'TLR adaptor interacting with SLC15A4 on the lysosome' (TASL), abrogated responses to endolysosomal TLR agonists in both primary and transformed human immune cells. Deletion of SLC15A4 or TASL specifically impaired the activation of the IRF pathway without affecting

SUBMITTER: Heinz LX 

PROVIDER: S-EPMC7610944 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature