Protocols for Dual Tracer PET/SPECT Preclinical Imaging.

ABSTRACT:

Background

Multi-tracer PET/SPECT imaging enables different modality tracers to be present simultaneously, allowing multiple physiological processes to be imaged in the same subject, within a short time-frame. Fluorine-18 and technetium-99m, two commonly used PET and SPECT radionuclides, respectively, possess different emission profiles, offering the potential for imaging one in the presence of the other. However, the impact of the presence of each radionuclide on scanning the other could be significant and lead to confounding results. Here we use combinations of ¹⁸F and ^99mTc to explore the challenges posed by dual tracer PET/SPECT imaging, and investigate potential practical ways to overcome them.

Methods

Mixed-radionuclide ¹⁸F/^99m

SUBMITTER: Blower JE 

PROVIDER: S-EPMC7610950 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature