Dissecting Clonal Hematopoiesis in Tissues of Classical Hodgkin Lymphoma Patients.

ABSTRACT: Clonal hematopoiesis predisposes to hematological malignancies. However, clonal hematopoiesis is understudied in classical Hodgkin lymphoma (cHL), a mature B-cell neoplasm exhibiting the most abundant microenvironment. We analyzed clonal hematopoiesis in 40 cHL cases by sequencing microdissected tumor cells and matched normal cells from blood and/or lymph nodes. Five patients had blood and/or tissue clonal hematopoiesis. In three of five patients (all failing first-line therapy), clonal hematopoiesis spread through the tissue microenvironment extensively, and featured mutant DNMT3A^R882H , KRAS^G60D and DNMT3A^R882H +TET2^Q1274 * in 33%, 92% and 60% of non-neoplastic cells, respectively. In the latter case, DNMT3A/TET2-

SUBMITTER: Venanzi A 

PROVIDER: S-EPMC7611041 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature