IRF5 guides monocytes toward an inflammatory CD11c⁺ macrophage phenotype and promotes intestinal inflammation.

ABSTRACT: Mononuclear phagocytes (MNPs) are vital for maintaining intestinal homeostasis but, in response to acute microbial stimulation, can also trigger immunopathology, accelerating recruitment of Ly6C^hi monocytes to the gut. The regulators that control monocyte tissue adaptation in the gut remain poorly understood. Interferon regulatory factor 5 (IRF5) is a transcription factor previously shown to play a key role in maintaining the inflammatory phenotype of macrophages. Here, we investigate the impact of IRF5 on the MNP system and physiology of the gut at homeostasis and during inflammation. We demonstrate that IRF5 deficiency has a limited impact on colon physiology at steady state but ameliorates immunopathology during Helicobacter hepaticus-induced colitis. Inhibition of IRF

SUBMITTER: Corbin AL 

PROVIDER: S-EPMC7611075 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature