Synaptic Loss in Primary Tauopathies Revealed by [¹¹ C]UCB-J Positron Emission Tomography.

ABSTRACT:

Background

Synaptic loss is a prominent and early feature of many neurodegenerative diseases.

Objectives

We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy (PSP) (Richardson's syndrome) and amyloid-negative corticobasal syndrome (CBS).

Methods

Forty-four participants (15 CBS, 14 PSP, and 15 age-/sex-/education-matched controls) underwent PET with the radioligand [¹¹ C]UCB-J, which binds to synaptic vesicle glycoprotein 2A, a marker of synaptic density; participants also had 3 Tesla MRI and clinical and neuropsychological assessment.

Results

Nine CBS patients had negative amyloid biomarkers determined by [¹¹ C]PiB PET and hence were deemed likely to have corticobasal degene

SUBMITTER: Holland N 

PROVIDER: S-EPMC7611123 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature