Structural insights into ligand recognition and activation of angiotensin receptors.

ABSTRACT: G protein-coupled angiotensin II receptors, AT₁R and AT₂R, are integral components of the renin-angiotensin system (RAS) that regulates blood pressure and fluid balance in humans. While AT₁R is a well-established target of angiotensin receptor blockers (ARBs) for managing hypertension and a prime system for studying biased signaling, AT₂R has been recognized as a promising target against neuropathic pain and lung fibrosis. In this review, we discuss how recent structural advances illuminate ligand-binding modes and subtype selectivity, shared and distinct features of the receptors, their transducer-coupling patterns, and downstream signaling responses. We also underscore the key ATR aspects that require further studies to fully appreciate the mec

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7611150 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature