Multi-stimuli responsive heterotypic hydrogels based on nucleolipids show selective dye adsorption.

ABSTRACT: Analogous to nucleic acids, the building blocks of nucleic acids and their derivatives are widely used to create supramolecular architectures for application mainly in the field of biomedicine. Here, we describe the construction of a multi-stimuli responsive and toxic dye adsorbing heterotypic hydrogel system formed using simple nucleoside-fatty acid conjugates. The nucleolipids are derived by coupling fatty acid chains of different lengths at the 5' position of ribothymidine and uridine. The nucleolipids in the presence of a strong base (e.g. NaOH) undergo partial hydrolysis, which triggers the self-assembly of the hydrolysed components resulting in the formation of heterotypic hydrogels. Notably, the gels are formed specifically in the presence of Na⁺ ions as other ions

SUBMITTER: Nuthanakanti A 

PROVIDER: S-EPMC7611312 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature