RocS drives chromosome segregation and nucleoid protection in Streptococcus pneumoniae.

ABSTRACT: Chromosome segregation in bacteria is poorly understood outside some prominent model strains^1-5 and even less is known about how it is coordinated with other cellular processes. This is the case for the opportunistic human pathogen Streptococcus pneumoniae (the pneumococcus)⁶, which lacks the Min and the nucleoid occlusion systems⁷, and possesses only an incomplete chromosome partitioning Par(A)BS system, in which ParA is absent⁸. The bacterial tyrosine kinase⁹ CpsD, which is required for capsule production, was previously found to interfere with chromosome segregation¹⁰. Here, we identify a protein of unknown function that interacts with CpsD and drives chromosome segregation. RocS (Regulator of Chromosome Segregation) is a

SUBMITTER: Mercy C 

PROVIDER: S-EPMC7611331 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature