Distinct actin-dependent nanoscale assemblies underlie the dynamic and hierarchical organization of E-cadherin.

ABSTRACT: Cadherins are transmembrane adhesion proteins required for the formation of cohesive tissues.^1-4 Intracellular interactions of E-cadherin with the Catenin family proteins, α- and β-catenin, facilitate connections with the cortical actomyosin network. This is necessary for maintaining the integrity of cell-cell adhesion in epithelial tissues.^5-11 The supra-molecular architecture of E-cadherin is an important feature of its adhesion function; cis and trans interactions of E-cadherin are deployed^12-15 to form clusters, both in cis and trans.^11,16-21 Studies in Drosophila embryo have also shown that Drosophila E-cadherin (dE-cad) is organized as finite-sized dynamic clusters that localize with actin patches at cell-cell junction

SUBMITTER: Chandran R 

PROVIDER: S-EPMC7611338 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature