Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus.

ABSTRACT: Early detection of esophageal neoplasia enables curative endoscopic therapy, but the current diagnostic standard of care has low sensitivity because early neoplasia is often inconspicuous with conventional white-light endoscopy. Here, we hypothesized that spectral endoscopy could enhance contrast for neoplasia in surveillance of patients with Barrett's esophagus. A custom spectral endoscope was deployed in a pilot clinical study of 20 patients to capture 715 in vivo tissue spectra matched with gold standard diagnosis from histopathology. Spectral endoscopy was sensitive to changes in neovascularization during the progression of disease; both non-dysplastic and neoplastic Barrett's esophagus showed higher blood volume relative to healthy squamous tissue (P = 0.001 and 0.02, re

SUBMITTER: Waterhouse DJ 

PROVIDER: S-EPMC7611389 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature