T2* placental MRI in pregnancies complicated with fetal congenital heart disease.

ABSTRACT:

Background

Congenital heart disease (CHD) is one of the most important and common group of congenital malformations in humans. Concurrent development and close functional links between the fetal heart and placenta emphasise the importance of understanding placental function and its influence in pregnancy outcomes. The aim of this study was to evaluate placental oxygenation by relaxometry (T2*) to assess differences in placental phenotype and function in CHD.

Methods

In this prospective cross-sectional observational study, 69 women with a fetus affected with CHD and 37 controls, whole placental T2* was acquired using a 1.5-Tesla MRI scanner. Gaussian Process Regression was used to assess differences in placental phenotype in CHD cohorts compared to our controls.

Results

SUBMITTER: Steinweg JK 

PROVIDER: S-EPMC7611398 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature