Flexible proton density (PD) mapping using multi-contrast variable flip angle (VFA) data.

ABSTRACT: Quantitative proton density (PD) maps measure the amount of free water, which is important for non-invasive tissue characterization in pathology and across lifespan. PD mapping requires the estimation and subsequent removal of factors influencing the signal intensity other than PD. These factors include the T1, T2* relaxation effects, transmit field inhomogeneities, receiver coil sensitivity profile (RP) and the spatially invariant factor that is required to scale the data. While the transmit field can be reliably measured, the RP estimation is usually based on image post-processing techniques due to limitations of its measurement at magnetic fields higher than 1.5 T. The post-processing methods are based on unified bias-field/tissue segmentation, fitting the sensitivity profile from image

SUBMITTER: Lorio S 

PROVIDER: S-EPMC7611405 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature