Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta-analysis.

ABSTRACT:

Objective

We performed a systematic review to summarize the efficacy and safety of in utero stem cells application in preclinical models with myelomeningocele (MMC).

Methods

The study was registered with PROSPERO (CRD42019160399). We searched MEDLINE, Embase, Web of Science, Scopus and CENTRAL for publications articles on stem cell therapy in animal fetuses with MMC until May 2020. Publication quality was assessed by the SYRCLE's tool. Meta-analyses were pooled if studies were done in the same animal model providing similar type of stem cell used and outcome measurements. Narrative synthesis was performed for studies that could not be pooled.

Results

Nineteen and seven studies were included in narrative and quantitative syntheses, respectively. Most used mesenchymal s

SUBMITTER: Kunpalin Y 

PROVIDER: S-EPMC7611444 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature