Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging.

ABSTRACT:

Objectives

Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it has been difficult to separate their effects. Herein, we study isolated and combined effects of hypertension and aging on central artery remodeling in multiple mouse models as a function of sex.

Methods

We biomechanically phenotyped the aorta as a function of two different methods of inducing hypertension [infusion of angiotensin II (AngII) or combining a high salt diet with inhibition of endothelial-derived nitric oxide synthase using L-NAME] in male and female wild-type and fibulin-5 null mice, the latter of which models aspects of aortic aging.

Results

Despite increasing blood

SUBMITTER: Spronck B 

PROVIDER: S-EPMC7611466 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature