Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer.

ABSTRACT: Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such lesions become cancer, whereas a third spontaneously regress. Although recent studies have described the presence of an active immune response in high-grade lesions, the mechanisms underpinning clinical regression of precancerous lesions remain unknown. Here, we show that host immune surveillance is strongly implicated in lesion regression. Using bronchoscopic biopsies from human subjects, we find that regressive carcinoma in situ lesions harbor more infiltrating immune cells than those that progress to cancer. Moreover, molecular profiling of these lesions identifies potential immune escape mechanisms specifically in those that pr

SUBMITTER: Pennycuick A 

PROVIDER: S-EPMC7611527 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature